Patient engagement has been called the “blockbuster drug of the 21st century.” Studies find that the more engaged and involved patients are with their health and health care, the better the outcomes. There is now growing interest in engaging patients in another aspect of health care: drug and device development. Borrowing methods from the fields of health economics, outcomes research, epidemiology, social sciences and marketing sciences, a new science of patient input has emerged, embracing data as a means for measuring patient-centered outcomes and quantifying patient preferences.