Adrian Hernandez, MD, MHS, is Executive Director, Duke Clinical Research Institute, and Vice Dean of the Duke University School of Medicine. Dr. Hernandez leads the largest academic research organization dedicated to developing, sharing, and implementing knowledge that improves health around the world through innovative clinical research. Core to the mission is to accelerate clinical evidence generation and implementation through outcomes research, clinical trials, comparative effectiveness, and health policy. He has led multiple large-scale patient-centered research programs with an emphasis to improve cardiovascular health sponsored by the NIH, PCORI, and industry. He currently leads national clinical study platforms aimed at improving health across multiple conditions through innovative methods such as NIH’s Health System Collaboratory, the PCORI-funded PCORnet®, the National Patient-Centered Clinical Research Network, and the regulatory-enabling trial platforms such as ACTIV-6 for repurposed medications.