Josh Denny is the Chief Executive Officer of the National Institutes of Health’s All of Us Research Program. All of Us seeks to enroll at least 1 million diverse participants to build an indispensable resource that accelerates precision medicine for all populations. Josh has been involved since the program’s inception. He was a member of the Advisory Committee to the NIH Director Precision Medicine Initiative Working Group, which developed the program’s initial scientific blueprint. He then led the program’s initial prototyping project and the All of Us Data and Research Center. Josh was named CEO of All of Us in January 2020. Prior to joining NIH, Josh was a professor of biomedical informatics and medicine, founding director of the Center for Precision Medicine, vice president for personalized medicine at Vanderbilt University Medical Center, and a practicing physician. There, he led discovery and implementation projects in precision medicine, including clinical pharmacogenomics and Vanderbilt’s DNA biobank. He was a pioneer in the use of electronic health records for genomics studies, including the initial descriptions of phenome‐wide association studies (PheWAS) and phenotype risk scores. He is an elected member of the National Academy of Medicine, the American Society for Clinical Investigation, and the American College of Medical Informatics.