Jonathan W. Simons is an American physician-scientist, medical oncologist, and leader in prostate cancer research. Simons is the Chief Science Officer and Medical Director of the Marcus Foundation. Simons’ laboratories at Johns Hopkins University and Emory University made original basic science contributions to understand the HIF-1 transcription factor in the molecular biology of cancer metastases, to the first development of human gene therapies for prostate cancer, and to defining the functions of immunomodulatory cytokines in prostate cancer bone metastases. He is the Founding Director of Georgia’s first NCI designated cancer center, the Winship Cancer Institute at Emory University. At Emory University, he was also Chief of Hematology and Oncology, Distinguished Professor of Hematology and Oncology at the Emory University School of Medicine and Professor of Material Sciences at the Georgia Institutes of Technology Nanotechnology Center. Before that, Dr. Simons was Director of the Molecular Pharmacology Program and Genetic Therapy Laboratory at the Johns Hopkins University School of Medicine. Dr. Simons received his bachelor’s degree from Princeton University, and his Doctor of Medicine degree from the Johns Hopkins University School of Medicine. He completed his residency in Internal Medicine at the Massachusetts General Hospital, Harvard Medical School, then began his career in cancer research as a Clinical Fellow in Medical Oncology and Postdoctoral Fellow in the Laboratory of Molecular Genetics under Dr. Bert Vogelstein both at The Johns Hopkins Oncology Center.