Technology giants made fortunes by disrupting their fields and creating life-changing innovations. Increasingly, they want to use their new personal wealth for good. These leaders have established foundations and are using philanthropic opportunities to inform their giving by leveraging the insights gained from their success in business. Their disruptive funding goals have contributed to innovations and far-reaching impacts. This session, featuring some of the disruptors, will explore the unique systems change that accompanies disruption-established philanthropic frameworks. The panelists will discuss opportunities to make a mark on our scientific ecosystems beyond the dollars invested.